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Dominated by the Greyhound company’s emblematic neon-lit vertical blade sign with the running dog image above a triangular marquee, this station’s curved entrance, blue ribbed porcelain-enamel metal panels, and narrow red brick courses accenting the yellow brick walls, imparts the sense of speed and modernity favored by Greyhound’s corporate architect, Arrasmith. The building served several carriers besides Greyhound. In December 1961, Vera Pigee and her daughter Mary Jane, members of the Clarksdale NAACP chapter, made this the first integrated bus station in the state by using the waiting room reserved for whites.